Cardiovascular: Abdominal aortic aneurysm, angina, atherosclerosis, cerebral ischemia, cerebrovascular lesion, heart block, peripheral cyanosis, phlebitis, thrombosis, and transient myocardial ischemia. IMITREX and AMERGE are registered trademarks of the GSK group of companies. The other brands listed are trademarks of their respective owners and are not trademarks of the GSK group of companies. The makers of these brands are not affiliated with and do not endorse the GSK group of companies or its products. MacLean MR, Smith GC, Templeton AG "Adverse reactions associated with sumatriptan.
F. Protect from light. Treatment with Imitrex Injection may cause somnolence and dizziness; instruct patients to evaluate their ability to perform complex tasks after administration of Imitrex Injection. It's a good idea to avoid or replacement products for several hours after taking these medicines. or other forms of nicotine can increase the side effects of ergotamines. Imitrex Injection is not indicated for the prevention of migraine or cluster headache attacks. The Pen will only work when the Safety Catch is released.
Neither of these adverse events was associated with a serious clinical outcome. The figure uses Kaplan-Meier product limit Survivorship Plot. AUC and C max and a T max 40 minutes earlier compared to the healthy subjects. Dogs receiving oral sumatriptan developed corneal opacities and defects in the corneal epithelium.
Imitrex, AMERGE, and TREXIMET are registered trademarks of the GlaxoSmithKline group of companies. The other brands listed are trademarks of their respective owners and are not trademarks of GlaxoSmithKline. The makers of these brands are not affiliated with and do not endorse GlaxoSmithKline or its products. Review all your prescription and nonprescription and dosages with your doctor or pharmacist. Many medicines, by themselves or in combination with other medicines, can cause mental confusion. Also, confusion may occur when medicines interact in your body. If you see several doctors, make sure that they all know what other medicines you are taking. Have all of your filled at the same pharmacy. Ask your doctor or pharmacist whether the combination of your medicines could cause problems.
IMITREX Injection is administered to treat any subsequent attacks. What is the most important information I should know about Imitrex? The use of Imitrex Injection is contraindicated in patients with ischemic or vasospastic CAD. There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of Imitrex Injection. Some of these reactions occurred in patients without known CAD. You get a cluster headache when a specific nerve pathway in the base of your is activated. That signal seems to come from a deeper part of the called the hypothalamus, where the "internal biological clock" that controls your and wake cycles lives. If your symptoms are only partly relieved or your headache returns, 2 hours after the injection you may switch to sumatriptan taken by mouth instead of using a second injection. After the initial injection you may take sumatriptan by mouth every 2 hours if needed to a maximum of 100 milligrams of tablets in a 24-hour period. IMITREX is working for you. See Drug Reference for a full list of side effects. Drug Reference is not available in all systems. Corneal Opacities: Sumatriptan causes corneal opacities and defects in the corneal epithelium in dogs; this raises the possibility that these changes may occur in humans.
Overall, the frequency of adverse reactions reported in the trials of cluster headache was generally lower than in the migraine trials. Exceptions include reports of paresthesia 5% Imitrex Injection, 0% placebo nausea and vomiting 4% Imitrex Injection, 0% placebo and bronchospasm 1% Imitrex Injection, 0% placebo. Hepatic: Elevated liver function tests. Care should be taken to exclude other potentially serious neurologic conditions before treating headache in patients not previously diagnosed with migraine or cluster headache or who experience a headache that is atypical for them. There have been rare reports where patients received sumatriptan for severe headaches that were subsequently shown to have been secondary to an evolving neurologic lesion see . For a given attack, if a patient does not respond to the first dose of sumatriptan, the diagnosis of migraine or cluster headache should be reconsidered before administration of a second dose. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see Drug Interactions section. As you age, it is normal to experience some memory lapses. Usually, an occasional memory lapse does not mean you have a serious problem. After each use the Pen must be put back into the Carrying Case to reset the white Priming Rod before the next use. Pregnancy Registry: To monitor fetal outcomes of pregnant women exposed to IMITREX, GlaxoSmithKline maintains a Sumatriptan Pregnancy Registry. Physicians are encouraged to register patients by calling 800 336-2176. Consult your doctor before -feeding. CAD, female with surgical or physiological menopause, or male over 40 years of age unless a cardiovascular evaluation provides satisfactory clinical evidence that the patient is reasonably free of coronary artery and ischemic myocardial disease or other significant underlying cardiovascular disease. The sensitivity of cardiac diagnostic procedures to detect cardiovascular disease or predisposition to coronary artery vasospasm is modest, at best. Burning, tingling, dryness or pain in the nose nasal spray. Ways to manage your time. Imitrex. These reports include reactions similar in nature to those reported rarely in adults, including stroke, visual loss, and death. theophylline
IMITREX Injection. All reported events are included except those already listed in the previous table, those too general to be informative, and those not reasonably associated with the use of the drug. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Imitrex is a prescription medicine used to treat acute migraine headaches with or without aura in adults. Fast or slow heartbeat. Imitrex passes into your breast milk and may harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take Imitrex. Discontinue IMITREX Injection if a cerebrovascular event occurs. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Do not flush down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container. IMITREX Injection is contraindicated. Ability to Perform Complex Tasks: Treatment with Imitrex Tablets may cause somnolence and dizziness; instruct patients to evaluate their ability to perform complex tasks after administration of Imitrex Tablets. This medication should be taken only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. These side effects can increase the risk of falling. efil.info albenza
Close the Carrying Case lid. Call your doctor if your headache does not go away at all after using the first sumatriptan dose. Pain, swelling, bleeding, or bruising at the injection site may occur. The plot was constructed with data from patients who either experienced relief or did not require request rescue medication within a period of 2 hours following treatment. As a consequence, the data in the plot are derived from only a subset of the 258 headaches treated rescue medication was required in 52 of the 127 placebo-treated headaches and 18 of the 131 sumatriptan-treated headaches. Check with your pharmacist about how to dispose of unused medicine.
There is no evidence that establishes that sumatriptan is a human teratogen; however, there are no adequate and well-controlled studies in pregnant women. IMITREX Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor or if you have questions about the ingredients in your brand. Injection in pregnant women. Rebound headaches were a problem in my teens. When Imitrex came out I was very impressed by how effective it was. I have been using it for about 10-12 years and I am now experiencing some problems with my migraines not easing up like they used too. Also, I have began to experience "leg migraines" with my regular migraines. They only react to the statdose injection. In some cases, your doctor may prescribe stronger medicine if over-the-counter drugs don't stop your headaches. This Patient Information leaflet summarizes the most important information about IMITREX. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about IMITREX that is written for healthcare professionals. Imitrex Injection should continue for at least 10 hours or while symptoms or signs persist. Refer to storage information printed on the package. This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Read this Patient Information before you start taking Imitrex and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or treatment. price cardizem us
Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT 1 agonists. Discontinue Imitrex Injection if these disturbances occur. Imitrex Injection is contraindicated in patients with Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders. Not applicable. See How to Use section. One study of 735 consecutive migraine patients reported that chest symptoms are frequent, but rarely important adverse effects of primarily subcutaneous sumatriptan the active ingredient contained in Imitrex The risk of chest symptoms was reported to be patient dependent and not related, even opposite, to cardiovascular disease. This report contradicts the hypothesis that chest symptoms after sumatriptan are caused by cardiac ischemia. Safety and efficacy have not been established in patients younger than 18 years. There are many reasons why people have trouble taking their medicine. cheap tegretol reliable
Do you seem to get them after you eat certain types of food? Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT 1 agonists. Discontinue Imitrex Tablets if these disturbances occur. Imitrex Tablets are contraindicated in patients with Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders. A. Throw away the seal. Open the lid over the Syringe Cartridge. Store Imitrex tablets between 36 and 86 degrees F 2 and 30 degrees C. Store away from heat, moisture, and light. Do not freeze. Do not store at temperatures above 86 degrees F 30 degrees C. Do not store in the bathroom. Keep Imitrex tablets in the case provided. Throw away expired medicine as directed by your doctor the expiration date is printed on the treatment pack. Keep Imitrex tablets out of the reach of children and away from pets. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Ask your healthcare provider if you should take your first dose in a medical setting.
If you feel unwell in any other way or have any symptoms that you do not understand, you should contact your doctor immediately. Headache relief, as evidenced by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70% of the patients within 1 hour of a single 6-mg subcutaneous dose of IMITREX Injection. Headache relief was achieved in approximately 82% of patients within 2 hours, and 65% of all patients were pain free within 2 hours. You can take it as a pill or as a suppository if nausea or vomiting stops you from keeping anything down. Another form of ergotamine, called DHE 45 also treats them. You can get it as an injection or as a nasal spray. Drug-Associated Cardiac Events and Fatalities: Serious adverse cardiac events, including acute myocardial infarction, life-threatening disturbances of cardiac rhythm, and death have been reported within a few hours following the administration of IMITREX Injection or IMITREX sumatriptan succinate Tablets. Considering the extent of use of sumatriptan in patients with migraine, the incidence of these events is extremely low. If there is no improvement in your symptoms, do not take any more doses of this medication before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, you may use a second injection after one hour or as directed by your doctor. Do not use more than 12 milligrams in a 24-hour period. Do not reuse the syringe or the needle-free device. If you are using an auto-injector device, it may be re-used. Researchers say triptans have become extremely popular in migraine treatment since they were introduced a decade ago. But many doctors do not understand why the drugs work well in some patients and not at all in others and why their effectiveness varies in individual patients from one migraine attack to the next. Serious and sometimes fatal brain blood vessel problems like stroke have rarely happened with Imitrex tablets. Contact your doctor at once if you have confusion, one-sided weakness, or speech or vision changes. You should not use this medicine if you have uncontrolled high blood pressure, heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Oral treatment of pregnant rats with sumatriptan during the latter part of gestation and throughout lactation resulted in a decrease in pup survival. If you have a higher risk for heart problems see Precautions your doctor may perform a heart exam before you start taking sumatriptan. Sumatriptan may also be used for purposes not listed in this medication guide. What is the most important information I should know about Imitrex Statdose sumatriptan injection? If you continue to have tension headaches while you are getting treatment, you and your doctor may want to try another treatment. Avoid for at least 12 hours after using sumatriptan. Consult your doctor before -feeding. Prompt treatment allows you to get back to your normal routine and may decrease your need for other pain medications. brand paroxetine generico
Remove STAT dose Pen from s kin. Rarely, serious and sometimes fatal heart problems eg, heart attack, irregular heartbeat have happened within a few hours of using Imitrex spray. Contact your doctor at once if fast or irregular heartbeat; chest, throat, jaw, or neck tightness, pain, pressure, or heaviness; breaking out in a cold sweat; shortness of breath; numbness or tingling of an arm or leg; severe stomach pain, dizziness, or vomiting; or fainting occur. Discuss any questions or concerns with your doctor. Rare were and increased urination. Therefore, do not use this medication more often or for longer than prescribed. Imitrex, IMITREX STATdose Pen, and IMITREX STATdose System are registered trademarks of the GSK group of companies. The pain did not lessen when I was finished in the bathroom, but did go away after about 30 minutes. Are the headaches triggered by something in your environment, such as smells, noise, or some kinds of weather? Store easy-to-lose items in the same place each time after you use them. zentel
Usually the benefits of the medicine are more important than any minor side effects. They are usually triggered after pain medicine has worn off, prompting you to take another dose. Eventually you get a headache whenever you stop taking the drug. Be sure to take your migraine medicine only as prescribed by your doctor. Tingling or weakness in fingers or toes. Are you using inadequate contraception? Do not share this medication with others. Your healthcare provider may change your dose. Do not change your dose without first talking with your healthcare provider. Drowsiness may occur during a migraine or during its treatment with this drug. Do not drive or operate machinery until you know how this drug affects you. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Throw away the seal. Open the lid over the Syringe Cartridge. For adults, the usual dose is a single injection given just below the skin. It should be given as soon as the symptoms of your migraine appear, but it may be given at any time during an attack. A second injection may be given if your symptoms of migraine come back. If your symptoms do not improve following the first injection, do not give a second injection for the same attack without first consulting with your doctor. Do not have more than 2 injections in any 24 hours and allow at least 1 hour between each dose. Side Effects List Imitrex side effects by likelihood and severity.
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RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. IMITREX and certain other medicines can affect each other, causing serious side effects. One study of 735 consecutive migraine patients reported that chest symptoms are frequent, but rarely important adverse effects of primarily subcutaneous sumatriptan. The risk of chest symptoms was reported to be patient dependent and not related, even opposite, to cardiovascular disease. This report contradicts the hypothesis that chest symptoms after sumatriptan are caused by cardiac ischemia.
Take this medication by mouth with or without food as directed by your doctor, at the first sign of a migraine. The dosage is based on your medical condition and response to treatment. If there is no improvement in your symptoms, do not take more doses of this medication before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, you may take another dose at least two hours after the first dose. Do not take more than 200 milligrams in a 24-hour period. If your migraine symptoms go away and then come back, or if you have a partial response to the first dose, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses.
Break the task down into simple steps. You may find it helpful to give the person written instructions. Consult WARNINGS section for additional precautions. Take this only as needed when a occurs, as directed by your doctor. This medication should not be taken on a regular schedule. Never increase your dose of this medication or take it more often than prescribed by your doctor.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. I” on one side and “25” on the other in blister packs of 9 tablets NDC 0173-0735-00. If you are not sure if you have these types of migraines, ask your healthcare provider. For adults, the usual dose is a single injection given just below the skin. IMITREX in their causation cannot be reliably determined. All reported events are included except those already listed, those too general to be informative, and those not reasonably associated with the use of the drug.